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TGF-β signaling and biology

Edited by: Dr Ying Zhang

Collection published: 28 December 2011

chart TGF-β and its related factors regulate a broad range of cellular functions, including proliferation, differentiation, apoptosis, migration, and adhesion. These factors are also very important in the pathogenesis of cancer and many other diseases.

Although much has been known about the TGF-β signaling pathway since the discovery of Smads 15 years ago, remarkable progress has been made in revealing details of different regulatory mechanisms that afford a full range of control of the biological functions of these factors in the TGF-β family. Specific physiological and pathological roles of TGF-β/Smad in different cellular context also start to emerge. This collection of review articles provides a broad, albeit not all-inclusive, overview of the latest breakthroughs and developments in TGF-β signaling and biology.

		Review Unraveling the biological functions of Smad7 with mouse models Lu Zhu, Susie Chen, Yan Chen Cell & Bioscience 2011, 1:44 (28 December 2011) Abstract \| Full text \| PDF \| PubMed
		Review Non-degradative ubiquitination in Smad-dependent TGF-β signaling Liu-Ya Tang, Ying E Zhang Cell & Bioscience 2011, 1:43 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Partners in crime: the TGFβ and MAPK pathways in cancer progression Douglas A Chapnick, Lisa Warner, Jennifer Bernet, Timsi Rao, Xuedong Liu Cell & Bioscience 2011, 1:42 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Roles of TGFβ signaling Smads in squamous cell carcinoma Gangwen Han, Xiao-Jing Wang Cell & Bioscience 2011, 1:41 (28 December 2011) Abstract \| Full text \| PDF \| PubMed
		Review Mechanism and Regulation of Nucleocytoplasmic Trafficking of Smad Xiaochu Chen, Lan Xu Cell & Bioscience 2011, 1:40 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Editorial A special issue on TGF-β signaling and biology Ying E Zhang Cell & Bioscience 2011, 1:39 (28 December 2011) Abstract \| Full text \| PDF \| PubMed

		Review Unraveling the biological functions of Smad7 with mouse models Lu Zhu, Susie Chen, Yan Chen Cell & Bioscience 2011, 1:44 (28 December 2011) Abstract \| Full text \| PDF \| PubMed
		Review Non-degradative ubiquitination in Smad-dependent TGF-β signaling Liu-Ya Tang, Ying E Zhang Cell & Bioscience 2011, 1:43 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Partners in crime: the TGFβ and MAPK pathways in cancer progression Douglas A Chapnick, Lisa Warner, Jennifer Bernet, Timsi Rao, Xuedong Liu Cell & Bioscience 2011, 1:42 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Roles of TGFβ signaling Smads in squamous cell carcinoma Gangwen Han, Xiao-Jing Wang Cell & Bioscience 2011, 1:41 (28 December 2011) Abstract \| Full text \| PDF \| PubMed
		Review Mechanism and Regulation of Nucleocytoplasmic Trafficking of Smad Xiaochu Chen, Lan Xu Cell & Bioscience 2011, 1:40 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Editorial A special issue on TGF-β signaling and biology Ying E Zhang Cell & Bioscience 2011, 1:39 (28 December 2011) Abstract \| Full text \| PDF \| PubMed