Figure 3.

Various mechanisms regulate TGF-β receptor activity. (A) Regulation of TGF-β receptor activity by multiple receptor-binding proteins. BAMBI and ETV6-NTRK3 attenuates TGF-β receptor activity by interfering receptor heterocomplex formation, while FKBP12 blocks GS domain phosphorylation of TβRI by TβRII at the basal state. (B) Sumoylation promotes TβRI activity.