Golgi phosphoprotein 2 in physiology and in diseases
1 Department of Microbiology and Immunology, 1300 York Avenue, New York, NY, 10065, USA
2 Department of Pediatrics, Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA
3 Graduate Program in Immunology and Microbial Pathogenesis, Weill Graduate School of Medical Sciences, Cornell University, 1300 York Avenue, New York, NY, 10065, USA
4 School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China
5 State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
Cell & Bioscience 2012, 2:31 doi:10.1186/2045-3701-2-31Published: 10 September 2012
Golgi phosphoprotein 2 (GOLPH2, also termed GP73 and GOLM1) is a type II transmembrane protein residing in the cis and medial-Golgi cisternae. GOLPH2 is predominantly expressed in the epithelial cells of many human tissues. Under poorly defined circumstances, GOLPH2 can be cleaved and released to the extracellular space. Despite of its relatively “young age” since the first description in 2000, the physiological and pathological roles of GOLPH2 have been the subject that has attracted considerable amount of attention in recent years. Here, we review the history of GOLPH2’s discovery and the multitude of studies by many groups around the world aimed at understanding its molecular, cellular, physiological, and pathogenic activities in various settings.